Dissection of the chloroplast unfolded membrane protein response in Chlamydomonas reinhardtii
Increases in temperature and light intensity challenge protein homeostasis in plant cells because they enhance rates of thermal and oxidative protein unfolding. Our results point to the existence of a chloroplast protein quality control system that can sense and clear protein aggregates that have formed in or at the thylakoid membranes. This protein quality control system is the core of the chloroplast unfolded membrane protein response (cpUMPR). The goal of this project is to characterize the components of this quality control system and its substrates, and to elucidate triggers, sensors and signal transduction components of the cpUMPR.